How 34 Pegs Fit into 26 + 8 Holes in the Flagellar Motor

How 34 pegs fit into 26 + 8 holes in the flagellar motor.

The article by Brown et al. (6) in this issue of Journal of Bacteriology makes it possible to integrate a series of investigations that have given us a high-resolution picture of the rotational flagellar motors of Escherichia coli and Salmonella enterica. Although details will surely differ, it should also serve as a model for the flagellar architectures found within a wide spectrum of prokaryo...

How baculovirus polyhedra fit square pegs into round holes to robustly package viruses.

Natural protein crystals (polyhedra) armour certain viruses, allowing them to survive for years under hostile conditions. We have determined the structure of polyhedra of the baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV), revealing a highly symmetrical covalently cross-braced robust lattice, the subunits of which possess a flexible adaptor enabling this supra-molecul...

Square Pegs and Round Holes

This article explores the relationship between the social construction of risk, uncertainty and evaluation in the field of development cooperation. It explores the assumption that risk and uncertainty are unusually high in development cooperation. Perceptions of risk and uncertainty are cultural constructs. Several authors have identified perceptions of uncertainty as one of the most important ...

Medical clergy: square pegs in holy holes?

Pounding Square Pegs into round Holes: Another Look at the Neoclassical Theory of Predatory Pricing

For more than forty years, economists have routinely rejected the postulate that economic theory should be realistic. Ever since Milton Friedman sketchily outlined a positive methodology for economics, most students of our science have come to endorse Friedman’s view and have claimed that the only quality standard of economic reasoning was its predictive power. Good theories yield fairly correc...